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Dr Iván Álvarez-Twose

Allergology

Dr Iván Álvarez-Twose

Specialist in
  • Mastocytosis and Mast Cell Activation Syndrome.
  • Hereditary alpha-tryptasemia.
  • Hypereosinophilic syndrome.
«Committed to translating the complexity of mastocytosis into precise clinical decisions based on evidence and experience.»
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Professional profile

A specialist in haematology and haemotherapy with extensive clinical experience in the diagnosis and management of mastocytosis and mast cell activation syndromes. He works in both clinical care and research, and is involved in centres of excellence and specialised national and international networks.

His clinical practice focuses on the integration of clinical, immunophenotypic and molecular data to inform diagnostic and therapeutic decision-making in complex haematological disorders.

Education

Medical training and specialisation in haematology, with academic and research experience in the field of mast cell disorders.

2017 | Doctor of Medicine. University of Alcalá.
2003 | Specialist in Haematology and Haemotherapy (MIR). Ramón y Cajal University Hospital.
1997 | Bachelor’s degree in Medicine and Surgery. University of Alcalá.

Professional experience

Clinical and research work carried out in hospitals and specialist centres, with a particular focus on mast cell disorders.

2022 – 2026 | Haematologist. Blue Healthcare Clinic.
2016 – Present | Coordinator of the Castilla-La Mancha Institute for Mastocytosis Studies (CLMast). Virgen del Valle Hospital, Toledo.
2007 – Present | Haematologist. Institute for the Study of Mastocytosis of Castilla-La Mancha (CLMast). Virgen del Valle Hospital, Toledo.
2006 – 2007 | Haematologist. Lanzarote General Hospital.
2004 – 2005 | Haematologist. Virgen de la Luz Hospital, Cuenca.
2003 – 2004 | Researcher. Research Institute of the Hospital de la Santa Creu i Sant Pau, Barcelona.
1999 – 2003 | Resident in Haematology and Haemotherapy. Ramón y Cajal University Hospital.

Scientific publications

Research focusing on mastocytosis and mast cell disorders, with publications in high-impact international journals.

2023 | Rama TA, Henriques AF, Matito A, et al. Bone and cytokine markers associated with bone disease in systemic mastocytosis. J Allergy Clin Immunol Pract. 2023;11(5):1536–1547. doi:10.1016/j.jaip.2022.12.012
2022 | Rama TA, Torrado I, Henriques AF, et al. Mast cell activation syndromes: comparison between two scoring models to predict mast cell clonality. J Allergy Clin Immunol Pract. 2022;11(3):908–919.e4. doi:10.1016/j.jaip.2022.10.027
2016 | Álvarez-Twose I, Jara-Acevedo M, Morgado JM, et al. Clinical, immunophenotypic, and molecular characteristics of well-differentiated systemic mastocytosis. J Allergy Clin Immunol. 2016;137(1):168–178. doi:10.1016/j.jaci.2015.06.033
2013 | Alvarez-Twose I, Zanotti R, González-de-Olano D, et al. Non-aggressive systemic mastocytosis without skin lesions associated with insect-induced anaphylaxis exhibits unique features compared with other indolent forms of systemic mastocytosis. J Allergy Clin Immunol. 2013;133(2):520–528. doi:10.1016/j.jaci.2013.06.033
2010 | Alvarez-Twose I, González de Olano D, Sánchez-Muñoz L, et al. Clinical, biological and molecular characteristics of clonal mast cell disorders presenting with symptoms of systemic mast cell activation. J Allergy Clin Immunol. 2010;125:1269–1278. doi:10.1016/j.jaci.2010.03.002

Areas of special focus

Clinical practice focusing on mast cell disorders and other complex haematological conditions, including:

  • Mastocytosis.
  • Mast cell activation syndrome.
  • Hereditary alpha-tryptasemia.
  • Hypereosinophilic syndrome.
  • Chronic myeloproliferative neoplasms.

Techniques and procedures

Application of advanced diagnostic and therapeutic techniques in haematology, including:

  • Bone marrow aspiration and biopsy.
  • Skin biopsy.
  • Targeted therapies (monoclonal antibodies and tyrosine kinase inhibitors).
  • Molecular studies.
  • Flow cytometry.

Accreditations and memberships

Membership of scientific networks and societies relating to haematology, including:

  • European Competence Network on Mastocytosis.
  • Spanish Society of Haematology and Haemotherapy (SEHH).
  • Spanish Mastocytosis Network.

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