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Prof. Julio García Aguilar

Oncological Surgery

Prof. Julio García Aguilar

Specialist in

  • Colorectal cancer

  • Minimally invasive surgery (laparoscopic and robotic)

  • Advanced colorectal surgery

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Professional profile

A colorectal surgeon with extensive experience in the surgical treatment of colorectal cancer. His work focuses on minimally invasive surgery, including laparoscopic and robotic approaches, as well as on the development of organ-preserving strategies for rectal cancer.

He has combined clinical practice with translational research, aimed at improving oncological outcomes, optimising patients’ quality of life and identifying biomarkers predictive of treatment response.

Education

Medical and surgical training undertaken in Spain and the United States, specialising in general surgery and colorectal surgery.

1992 – 1993 | Fellow in Colorectal Surgery. University of Minnesota.
1991–1992 | Chief Resident, Surgery. Beth Israel Hospital.
1990–1991 | Senior Resident, Surgery. Beth Israel Hospital.
1990 | Doctor of Medicine (PhD). Complutense University of Madrid.
1986–1989 | Postdoctoral Fellow in Surgery. Harvard Medical School.
1985–1986 | Junior Resident, Surgery. Beth Israel Hospital.
1980 – 1985 | Training in Surgery. Complutense University of Madrid.
1979 | Bachelor’s Degree in Medicine and Surgery. Complutense University of Madrid.

Professional experience

Clinical work in oncological colorectal surgery, with clinical, organisational and leadership responsibilities in specialist units.

2012 – Present | Colorectal surgeon and head of the surgical oncology unit.

Scientific publications

Research focusing on colorectal cancer, organ preservation, immunotherapy and tumour biology, with participation in multicentre studies and publications in high-impact journals.

2025 | Cercek A, Foote MB, Rousseau B, Garcia-Aguilar J, et al. Non-operative management of mismatch repair-deficient tumours. N Engl J Med. 2025;392(23):2297–2308.
2025 | Moorman A, Benitez EK, Cambulli F, Garcia-Aguilar J, et al. Progressive plasticity during colorectal cancer metastasis. Nature. 2025;637(8047):947–954.
2022 | Garcia-Aguilar J, Patil S, Gollub MJ, Kim JK, et al. Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy. J Clin Oncol. 2022;40(23):2546–2556.
2022 | Cercek A, Lumish M, Sinopoli J, Garcia-Aguilar J, et al. PD-1 blockade in mismatch repair-deficient, locally advanced rectal cancer. N Engl J Med. 2022;386(25):2363–2376.
2022 | Nguyen B, Fong C, Luthra A, Garcia-Aguilar J, et al. Genomic characterisation of metastatic patterns from prospective clinical sequencing of 25,000 patients. Cell. 2022;185(3):563–575.e11.

Areas of special focus

Clinical practice focusing on colorectal oncology, including:

  • Colon cancer.
  • Rectal cancer.
  • Locally advanced colorectal cancer.
  • Metastatic colorectal cancer.
  • Tumours with molecular alterations predictive of therapeutic response.

Techniques and procedures

Application of advanced surgical techniques in colorectal surgery, including:

  • Minimally invasive surgery.
  • Laparoscopic surgery.
  • Robotic surgery.
  • Organ-preserving strategies in rectal cancer.
  • Assessment of biomarkers in therapeutic decision-making.

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